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Awards

Topic Information Award/Contract Number Proposal Information Company Performance
Period
Award/Contract
Value
Abstract

H-SB05.2-001
HANDHELD BIOLOGICAL DETECTION SYSTEM

NBCHC060017 0521013
(FY05.2 Phase I)
Hand-Held MENTOR for Biological Threat Material Detection and Identification

Menon and Associates, Inc.
12282 Libelle Ct.
San Diego, CA 92131-3845

12/15/2005
to
06/30/2006
$100,000.00

Emergency responders require a hand-held instrument in the field for screening specific sites for biological threat materials. In Phase I we will complete a design for an instrument, called MENTOR, which meets the needs and specifications of the emergency response teams. Innovative methods will be used to test electronic and software modules to transition the MENTOR system from a desktop to hand-held system. In Phase II we plan to complete the design and build the final fieldable prototype system. This system will then be tested in collaboration with the emergency response teams, including BioWatch program, in the field. Initial tests using the MENTOR proved that it detects and identifies toxins, bacteria and virus instantaneously. It uses parts that can be made rugged, with miniature modules that can be easily maintained and replaced. Connectivity to the internet allows data downloads and alerts. User friendly software and display enable operating the system in hazardous conditions. MENTOR can be used to monitor areas such as airports, shopping malls, mail, cargo, border and customs.

H-SB05.2-001
HANDHELD BIOLOGICAL DETECTION SYSTEM

NBCHC060032 0521157
(FY05.2 Phase I)
Fast, easy, reliable first responder bioterrorism detection system

Investigen, Inc.
750 Alfred Nobel Drive
Suite 109
Hercules, CA 94547-1836

02/01/2006
to
08/15/2006
$99,600.00

The proposed research is to determine feasibility of developing a stable, simple, rapid method of detecting the nucleic acid (NA) from bioterrorism agents. This method would be based on Investigen's novel and elegant "smartDNA" technology. This system utilizes a peptide nucleic acid probe cocktail to produce a rapid color change when probes hybridize to complementary NA sequences. Phase 1 will: 1) demonstrate detection of multiple agents; 2) develop collection hardware and consumables; 3) develop processing hardware and consumables, 4) develop detection hardware and consumables, and 5) validate system performance. With this validation of the feasibility of developing a smartDNA first responder bioterrorism agent detection system, we would develop the system to detect category A bioterrorism agents. The intention is to create a commercial diagnostic assay to detect bioterrorism agents that is so simple and stable that one could be in every locality. Such a test could be used in peripheral locations away from a central lab. This would help response to and may even deter bioterrorism attacks. smartDNA is uniquely suited to situations where there is not easy access to a central lab and a NA test is ideal. These include disease assessment in public health settings and agriculture.

H-SB05.2-001
HANDHELD BIOLOGICAL DETECTION SYSTEM

NBCHC060031 0521268
(FY05.2 Phase I)
BioPhalanx, a hand portable discrete monolithic microarray biothreat detector

Arcxis Biotechnologies
18858 Carlton Ave
Castro Valley, CA 94546-2908

12/15/2005
to
06/30/2006
$100,000.00

The focus of this proposal is to develop BioPhalanx a rapid, hand portable, robust detection system for multiplexed detection of bio-threats, in harsh environments. We have developed a new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability. This type of analysis will greatly reduce false positives and false negatives; in addition it is reusable and eliminates special storage requirements for reagents. The Arcxis Biotechnologies team has realized specific technical advancements in the optimization of hybridization assays for nucleic acid detection on porous polymer monoliths (PPM). We have further developed the ability to perform rapid and complete solubilisation of viruses, vegetative bacteria and bacterial spores with an ultra high temperature solubilisation protocol. Combining these proprietary technologies provides the ability to perform rapid highly multiplexed analysis of a variety of bioagents, including bacteria viruses, and protein biotoxins. The BioPhalanx system is designed to perform completely automated sample preparation and analysis, in a time frame of five minutes or less. The assay is simple in design allowing users in personal protective equipment to easily operate the system. In all, the proposed BioPhalanx system is robust, simple to use, and addresses the goals of DHS and the first responder community.

H-SB05.2-001
HANDHELD BIOLOGICAL DETECTION SYSTEM

D08PC75304 (formerly NBCHC080067) 0522016
(FY05.2 Phase II)
Fast, Easy, Reliable First Responder Bioterrorism Detection System

Investigen, Inc.
750 Alfred Nobel Drive
Suite 109
Hercules, CA 94547-1836

03/01/2008
to
06/15/2010
$750,000.00

The proposed research is to develop the prototype of a hand-held first responder bioterrorism agent (BA) detection system that is threat level responsive, simple, stable and rapid for analyzing suspicious powders or aerosols for the presence of nucleic acid (NA) from BAs. Investigen's "smartDNA" system uses peptide nucleic acid probe-dye cocktails to promote a rapid color change when hybridized to target NA. The simplicity of smartDNA is its key attribute and contributes to the system's low unit and operating costs, projected reliability, low maintenance, low power usage, and ruggedness. Investigen will: (1) develop sensitive and specific smartDNA reagents with signatures for Francisella tularensis, Bacillus anthracis and Yersinia pestis, (2) develop system hardware and software, (3) develop consumables concepts and (4) validate system performance compared to current detection methods. Our intention is to create a commercial diagnostic system to detect BAs that is so simple and stable that one could be in every locality. The wide spread placement of this system in peripheral locations, away from central labs, could help in response to and may even deter bioterrorism attacks. In addition, the simple smartDNA system can be used for point-of-care diagnostics for environmental, agricultural, veterinary and medical applications.

H-SB05.2-001
HANDHELD BIOLOGICAL DETECTION SYSTEM

NBCHC070088 0523004
(FY05.2 Phase II)
BioPhalanx, a hand portable discrete monolithic microarray biothreat detector

Arcxis Biotechnologies
18858 Carlton Ave
Castro Valley, CA 94546-2908

07/02/2007
to
09/01/2009
$999,201.46

The following proposal describes the planned effort of Arcxis Biotechnologies in the development of a rapid portable biosensor, we call BioPhalanxTM. During the Phase I SBIR project, we developed an alpha prototype for rapid point-of-care/point-of-incident instrument for the discrimination of biological agents. Our main overarching technical goal is to eliminate the need for PCR based detection, while retaining the necessary sensitivity, selectivity, rapid response, and robustness required in rugged field environments. Having completed the Phase I effort, we confidently believe based on the data generated that we have demonstrated the feasibility, in terms of sensitivity, selectivity, rapid response of the assay approach. Further the externally deployed prototype system demonstrated instantaneous detection of threat genes for B. Anthracis. The primary goals of this proposed effort are to 1) increase the sensitivity of the device, 2) produce the pre-production prototype that will be deployed to between at least five customers for the detection of no less than 20 CDC category A, B, C viruses and bacteria, and 3) develop a manufacturable system that will allow cost-effective production and sales of the BioPhalanx.

H-SB05.2-005
METHODS TO DETERMINE STRUCTURAL STABILITY

NBCHC060014 0521045
(FY05.2 Phase I)
Structure Health-Assessing Wireless Sensors

Physical Optics Corporation
20600 Gramercy Place, Building 100
Torrance, CA 90501-1821

12/15/2005
to
06/30/2006
$99,996.00

To address the need for on-the-spot structural stability assessment by emergency personnel, Physical Optics Corporation (POC) proposes to develop a new wireless stand-off structure integrity monitoring system, Structure Health Assessing Wireless Sensors (SHAWS), based on multimodal remote sensors, a wireless communication module, and handheld receivers. The SHAWS system evaluates the stability of structures by means of multimodal, hybrid sensors in terms of structure displacement, dislocation, and strain changes. The sensors' output signals are transmitted for instant alarm/warning to multiple users through a wireless network. In prototyping the SHAWS system, POC will make use of its customized sensor packages such as an integrated inertial MEMS, optical proximity sensors, and smart material strain sensors, and wireless networking systems. In Phase I POC will demonstrate a functional SHAWS prototype with a testbed, showing that SHAWS can accurately monitor a structure's state-of-health in real time. In Phase II POC plans to develop a packaged SHAWS system and demonstrate full functionality in realistic environments. POC's SHAWS commercial applications include data processing/storage for shipboard sensors, where remote data measurements and updates are required for control and monitoring purposes such as transportation, logistics, equipment tracking and maintenance, and security.

H-SB05.2-005
METHODS TO DETERMINE STRUCTURAL STABILITY

NBCHC060016 0521101
(FY05.2 Phase I)
Real-Time Holographic Structural Instability Evaluation System

Physical Optics Corporation
20600 Gramercy Place, Building 100
Torrance, CA 90501-1821

12/15/2005
to
06/30/2006
$99,989.00

To address the need for improved techniques to determine the structural stability buildings and other structures, Physical Optics Corporation (POC) proposes to develop a new Real-time Holographic Structural Instability Evaluation (RHOSIE) system based on novel temporally modulated holography (TMH), with acoustic excitation and highly sensitive rewritable photothermoplastic recording film. The RHOSIE system holographically records and reconstructs the surface vibration pattern as an indicator of material structure stability, characteristic of a material structure that is acoustically stimulated by a transducer. The overall vibration pattern recorded in the holograms can be read out by a CCD camera, and the data processed to extract the high-frequency components resulting from the stress distribution in the material structure of the building. The mapped stresses on the structure can be analyzed to quantify the structural integrity to warn of serious instability or pending collapse. In Phase I POC will design, analyze, and assemble a breadboard prototype to demonstrate the feasibility of RHOSIE. In Phase II we will focus on an optimized, miniaturized, and fully functional packaged portable prototype system for testing and evaluation at a HSARPA selected facility.

H-SB05.2-005
METHODS TO DETERMINE STRUCTURAL STABILITY

NBCHC060018 0521179
(FY05.2 Phase I)
Smart Joint system for in-situ monitoring of buildings

Acellent Technologies, Inc.
155 C-3 Moffett Park Drive
Sunnyvale, CA 94089-1331

12/15/2005
to
06/30/2006
$99,996.60

Acellent Technologies proposes to develop a smart joint structural health monitoring (SHM) sensor network that can autonomously assess in real time the structural stability of structures such as buildings. The sensor network will use a combination of large and small piezoelectric actuators and sensors to characterize damage in, and monitor the rigidity of components of the building primary structure, and fiber optic temperature sensors to monitor the structural temperature at various locations in the building. Acellent's existing sensor network technology will be used as the basis for the proposed development. Innovations will include a redesigned sensor/actuator arrangement, the integration of fiber optic temperature sensors and software that will provide a map of the structural damage, rigidity and temperature information that will be used to provide a real time assessment of the building structural integrity. An additional development will be to use the piezoelectric sensors to recognize sound and/or voice transmitted through the structure to allow search and rescue personnel to pin-point the location of survivors and determine what they are trying to say through an easy conversion to text messaging. Phase I will focus on preliminary prototyping and technology demonstrations while Phase II will focus on complete system development.

H-SB05.2-005
METHODS TO DETERMINE STRUCTURAL STABILITY

NBCHC070065 0522011
(FY05.2 Phase II)
Structure Health-Assessing Wireless Sensors

Physical Optics Corporation
20600 Gramercy Place, Building 100
Torrance, CA 90501-1821

03/15/2007
to
06/25/2009
$749,988.00

To address the Department of Homeland Security need for a real-time structural stability monitoring system, Physical Optics Corporation (POC) proposes to develop the Structure Health-Assessing Wireless Sensors (SHAWS) that warn emergency responders of serious structural instability or pending collapse. The SHAWS is based on multimodal wireless remote sensor nodes (RSNs), instability detection software and handheld receivers. The SHAWS combines multiple sensor modalities in a single package. In Phase I POC successfully demonstrated SHAWS feasibility by testing accurate multimodal, wireless RSN sensing and a data link to a handheld receiver. In a scaled demonstration, POC showed SHAWS instability warning capability in a mechanical testbed with software friendly to nontechnical users. In Phase II POC will advance the multimodal RSN, intelligent data analysis for early detection, and versatile handheld receivers, with practical remote RSN deployment. A prototype SHAWS system will be tested and its performance evaluated in a realistic environment with a local fire department. POC's SHAWS technology, developed for Homeland Security emergency crews, can also be useful for antiterror operations, protection of valuable equipment controlling access to buildings, home health monitoring, wireless machinery sensing, remote data logging for manufacturing, animal tagging, and waste management.

H-SB05.2-005
METHODS TO DETERMINE STRUCTURAL STABILITY

NBCHC070100 0522013
(FY05.2 Phase II)
Smart Joint System for In-situ Monitoring of Buildings

Acellent Technologies, Inc.
155 C-3 Moffett Park Drive
Sunnyvale, CA 94089-1331

09/24/2007
to
08/23/2009
$749,954.46

Acellent proposes to develop a smart joint structural health monitoring (SHM) sensor network that can autonomously assess in real time the structural stability of buildings. The sensor network will use piezoelectric transducers and temperature sensors to characterize damage in, and monitor the rigidity of components of the building primary structure. Acellent's existing sensor network technology will be used as the basis for the proposed development. Phase I focused on preliminary prototyping and technology demonstrations while Phase II will focus on complete system development. Innovations in Phase II will include development of a SmartDAQ sensor package that includes the piezoelectric transducers, temperature sensors, hardware, energy harvested power, battery, wireless data transmission and intelligent software. This will be used to provide a real time assessment of the building structural integrity. The data will be available for display to provide and early warning to first response and emergency personnel to ensure their safety prior to entering the building. An additional development will be to use the sensors to recognize sound and/or voice transmitted through the structure to allow search and rescue personnel to pin-point the location of survivors and determine what they are trying to say through an easy conversion to text messaging.

H-SB05.2-006
PORTABLE/TRANSPORTABLE DIRECTIONAL GAMMA RAY AND/OR DIRECTIONAL NEUTRON DETECTORS

NBCHC060045 0521004
(FY05.2 Phase I)
Innovative Gamma source finding array

Space Micro Inc.
10401 Roselle Street
Ste 400
San Diego, CA 92121-2256

12/15/2005
to
06/30/2006
$100,000.00

The high stress situations facing Security Staff responsible for detecting radiological threats to the United States is complicated by the need to identify these threats in complex backgrounds of natural and/or legitimately transported medical and industrial radiation sources. Although the operational constraints vary, a common need is to quickly provide Specific Isotope and Source Location information to enable situational assessment. Considerable gains have been made in developing and deploying the next generation of Isotope Identifiers but no acceptable tool is available outside of the laboratory for accurately and quickly resolving the Source Angular Location without heavy, movable shield material. Preliminary modeling by Space Micro indicates that the capabilities of Lanthanum Halides used in recent Isotope Identifiers coupled with an innovative geometric array and a unique algorithm will exploit the properties of Lanthanum Halides to enable resolving source angular direction to better than 15o. This Phase I proposal is for laboratory confirmation that this predicted angular resolution can be achieved and to provide a technical foundation for product commercialization. Since the scintillation material is commercially available, this approach will facilitate a relatively low risk program to quickly produce field prototypes that meet the performance requirements of our Homeland Defense Operators.

H-SB05.2-006
PORTABLE/TRANSPORTABLE DIRECTIONAL GAMMA RAY AND/OR DIRECTIONAL NEUTRON DETECTORS

NBCHC060021 0521074
(FY05.2 Phase I)
A Directional Gamma Auto Spectrometer

Aguila Technologies, Inc.
310 Via Vera Cruz, Suite 107
San Marcos, CA 92078-2631

12/15/2005
to
06/30/2006
$99,994.00

The Government is deploying a growing number of radiation detectors at U.S. borders, ports of entry and other key locations, intended to assist in the detection of a potential terrorist`s nuclear explosive device or radiological dispersal device. The most widely deployed radiation detector products today are radiation "pagers". Such products are unable to differentiate between natural radiation, legitimate and clandestine radioactive materials, resulting in a disturbingly high incidence of false positives. There is a need for a device that can provide radionuclide identification and spatial differentiation in portable unit. This proposal will develop a low-cost, battery-operated handheld radiation sensor with these features. The proposed sensor will allow trained personnel in the field to locate and identify potentially threatening radionuclides. It will differentiate radioactive sources as potentially dangerous or likely benign and provide radioemitter source direction, distance and size information. It is based on pixel array CdZnTe detectors, new multichannel detector readout ASICS, directionally-sensitive elements, state-of-the art high density packaging and novel software and firmware that can deconvolve nuclear spectra to identify myriad combinations of gamma radiation sources.

H-SB05.2-006
PORTABLE/TRANSPORTABLE DIRECTIONAL GAMMA RAY AND/OR DIRECTIONAL NEUTRON DETECTORS

NBCHC070028 0522009
(FY05.2 Phase II)
RADSITE: A Compact Directional Gamma Finder

Space Micro Inc.
10401 Roselle Street
Ste 400
San Diego, CA 92121-2256

05/11/2007
to
02/10/2009
$750,000.00

Commercially fielded Radiation Detectors do a fine job of measuring and identifying Gamma Radiation Sources, but are not able to provide an additional extremely useful capability to augment the radiological assessment missions of Law Enforcement, First Responder and Military Personnel; namely to enable quick standoff ability to find the radiation source or sources. Directional Gamma Finding is complicated by the fact that the environment includes considerable Naturally Occurring Radioactive Material (NORM) and legitimate Sources that along with scatter from the target source interfere with the azimuth determination. Space Micro Inc (SMI) has developed a Radiation Source Identification and Targeting (RADSITE(TM)) innovation that not only remotely detects and identifies Gamma Sources; but by use of a unique processing technique provides the operator with simultaneous threat Azimuth Directions. Significantly, this technology, protected by a provisional patent application, can be deployed in a rugged, portable package to nearly all mission locations. Phase I Bench Testing by SMI provided physical confirmation that our innovative array of Lanthanum Bromide (LaBr3) sensors could resolves source angular direction to better than +/- 5o. This Phase II proposal is for provision of Field Prototypes suitable for field evaluation to provide the foundation for product commercialization.

H-SB05.2-006
PORTABLE/TRANSPORTABLE DIRECTIONAL GAMMA RAY AND/OR DIRECTIONAL NEUTRON DETECTORS

NBCHC070029 0523001
(FY05.2 Phase II)
A Directional Gamma Auto Spectrometer

Aguila Technologies, Inc.
310 Via Vera Cruz, Suite 107
San Marcos, CA 92078-2631

05/01/2007
to
06/30/2008
$1,250,000.00

THIS IS A FAST TRACK PROPOSAL WITH SIGNIFICANT MATCHING FUNDS COMMITMENTS. The Government is deploying a growing number of radiation detectors at U.S. borders, ports of entry and other key locations, intended to assist in the detection of a potential terrorist`s nuclear explosive device or radiological dispersal device. The most widely deployed radiation detector products today are radiation "pagers". Such products are unable to differentiate between natural radiation, legitimate and clandestine radioactive materials, resulting in a disturb-ingly high incidence of false positives. There is a need for a device that can provide radionuclide identification and spatial differentiation in portable unit. This proposal will develop a portable radiation sensor technology with these features. The proposed sensor will allow trained personnel in the field to locate and identify potentially threatening radionuclides. It will differentiate radio-active sources as potentially dangerous or likely benign and provide radioemitter source direction, distance and size information. It is based on pixel array CdZnTe detectors, new multichannel detector readout ASICS, directionally-sensitive elements, state-of-the art high density packaging and novel software and high spectral resolution features to allow spectral identification of myriad combinations of gamma radiation sources. The Phase 2 proposal builds upon the demonstration system of Phase 1.