|Proposal Title:||Novel Electrostatics-based Sampler for Bioaerosol Collection in Small Analysis Volumes|
|Topic Title:||AEROSOL COLLECTION INTO LOW ANALYSIS VOLUMES (ACLAV)|
|Organization:||CFD Research Corporation|
|Address:||215 Wynn Dr.
Huntsville, AL 35805-1926
|Abstract:||Current bioaerosol monitoring and evaluation systems are largely based on collection of airborne pathogens in a liquid medium, followed by the detection of the targets of interest. While available aerosol collection technologies employ large collection volumes, biosensors are capable of processing only a small fraction of the collection volume. Our overall objective is to design and demonstrate a novel electrostatics-based sampler that is capable of directly capturing the incoming stream of aerosol particles in very small collection volumes. This reduced collection volume provides multiple benefits including greater assay sensitivity, reduced probabilities of false negatives and reduction in overall logistical burden. Building on CFDRC's proven electrostatic collection technology, we will demonstrate aerosol collection in a small volume of collection buffer. Our main challenge is to increase throughput to 100 L/min while maintaining high efficiencies and minimizing losses. During Phase I, collection, concentration and capture efficiencies factors will be clearly demonstrated, using a judicious combination of computer-aided design/analysis and experimental testing with BSL-1 organisms. Phase II will focus on prototype integration and testing with an extensive set of class-based simulants and agents. An inter-disciplinary team has been assembled to ensure project success.|
|Period of Performance:||09/01/2006 - 03/15/2007|