Topic Information Award/Contract Number Proposal Information Company Performance

Malware Prediction for Situational Understanding and Preemptive Cyber Defense

HSHQDC-17-C-00044 HSHQDC-16-R-00012-H-SB016.1-003-0021-II
(HSHQDC-16-R-00012 Phase II)
InnerAwareness: Preemptive Cyber Defense and Situational Understanding Through Memory-Oriented Cyber Genomics and Physiology

ZeroPoint Dynamics, LLC
130 Hamilton Hedge Pl
Cary, NC 27519-9144


Motivated by a real operational need to tackle threats posed by the onslaught of constantly evolving exploits and malware, this proposal describes techniques for dynamically analyzing malware that addresses weaknesses in the status quo by (i) focusing on memory-oriented artifacts without the use of traditional sandbox hooks, while at the same time (ii) providing operators with enhanced situational understanding and preemptive malware and exploit defenses. Specifically, we will explore the design and implementation of novel memory-oriented techniques for conducting automated analysis of malware binaries (i.e. so called cyber-physiology techniques) to not only assist analysts in understanding the their function and intent, but also produce a novel set of outputs (i.e. artifacts, behaviors, code constructs) that, combined, concisely represent human understandable malware and exploit fingerprints. Second, we will design and implement so called cyber-genomics techniques for both individually using and collating a multitude of these malware fingerprints over time to not only aid in determining their identity, lineage, and provenance, but also identify trends in fingerprint components to pinpoint key distinguishing characteristics of malware that are likely to be utilized in future waves of attack.

Deterministic Augmentation of RF Transmissions for PNT

70RSAT19C00000015 FY18.1-H-SB018.1-004-0002-II
(FY18.1 Phase II)
Augmented Commercial Radio for Navigation (ACORN)

Setter Research, Inc.
3306 Windrift Drive
Greensboro, NC 27410-3950


The Global Positioning System (GPS) and other global navigation satellite systems (GNSS) are the critical providers of position, navigation, and time (PNT) information to an almost uncountable number of users and applications. Widespread dependence on GPS has led to awareness that GPS data availability is a single point of failure for many systems and applications. In addition, GPS signals are very weak, leading to threats of jamming (interference) and spoofing (transmission of false signals) from both hostile and accidental sources. These risks to GPS have significant economic and public health and safety impacts. Users need assured PNT, that systems and operations can be assured of both the availability and integrity of PNT data. Augmented Commercial Radio for Navigation (ACORN) is a general purpose, nationwide PNT capability, that operates by augmenting existing commercial broadcast transmissions to provide high-accuracy, high-availability, and high-integrity PNT data. The Phase I study indicates that ACORN should provide more accurate data than GPS L1 C/A code and support an unlimited number of simultaneous users operating indoors, outdoors, and airborne. The Phase II effort will implement and test prototype devices, validate performance expectations via test, and prepare for commercialization.


NBCHC070099 0522007
(FY05.2 Phase II)
Handheld Multianalyte Biosensor Platform

TIRF Technologies
951 Aviation Parkway, Suite 700
Morrisville, NC 27560-9225


The overall goal of this project is to develop a handheld biosensor for rapid and sensitive detection of multiple biological analytes. The project primarily addresses the needs of first responders for detection of bioterrorism agents directly at the site of suspected attack. TIRF Technologies proposes to develop such handheld biosensor based on total internal reflection fluorescence (TIRF) combined with electrochemistry (TIRF-EC). The envisioned TIRF-EC sensor is capable of detecting multiple bioanalytes in a matter of several seconds or a few minutes. The detection limit is at the level of single molecules. Inexpensive sensor cartridge carries array of receptor molecules and contains all reagents for detection. The sensor cartridge is also equipped with a module, which performs sample preparation. To carry out the analysis, the operator inserts the cartridge, applies unpurified sample to the entrance port, and in several minutes reads the results of analysis at the handheld device. If manufactured massively, the envisioned biosensor will cost $200-400, and disposable sensor cartridges - $5-10. In Phase I, the feasibility of highly multiplexed handheld TIRF-EC biosensor was successfully demonstrated. A 4-pixel prototype of TIRF-EC sensor was built and tested. Since the electronics of 4-pixel prototype is capable of supporting up to 100 photodetectors, only several quantitative steps separate the project from building a highly multiplexed handheld biosensor. This Phase II application seeks support to develop a 64-analyte handheld biosensor based on TIRF-EC. Phase I also demonstrated the feasibility of rapid sample preparation integrated into miniature TIRF-EC sensor cartridge. In Phase II, 64-pixel TIRF-EC sensor and respective sensor cartridges will be developed, prototyped and validated in conjunction with reagentless fluorescence assays for detection DNA/RNA and protein signatures of bioterrorism agents. The envisioned handheld TIRF-EC biosensor will enable first responders with a powerful tool capable to rapidly detect multiple bioterrorism agents with minimum false positive and false negative responses. This will allow for designing efficient counter measures and avoiding unnecessary interruptions of normal life. TIRF-EC biosensor represents a flexible platform technology; it can be reconfigured for other applications. Prospective market for the envisioned handheld biosensor encompasses biomedical, forensic, food analysis, agricultural, and environmental applications.

Engineered Building Materials

N10PC20042 0822004
(FY08.2 Phase II)
3WEAVE Fabric/Composite Panels for Blast Protection

3TEX Inc.
109 MacKenan Drive
Cary, NC 27511-7903


Based on the results of the Phase I project, it was shown that 3TEX`s unitary 3D woven E-Glass billet reinforced composite panels have excellent potential to be used as blast mitigating material for protecting buildings. Fibers and resins used in the Phase I were selected with affordability and fire resistance as the major considerations. In the Phase II effort proposed, the same fiber and resin will be used. The 3D woven billet preform design will be optimized and, based on the new geometry, predictive analysis will be conducted to determine that performance under shock loading is still at the same level found in Phase I or better. The new material will be produced and tested in the University of Rhode Island (URI) shock tube for validation. Large scale blast testing of mock-up concrete walls will be conducted using three different mounting approaches. An innovative attenuator will be used to reduce the shock load transmitted through the mounting bolts to the wall. A patented coupler will also used to simulate the joining of two panels in a vertical installation. At the end of the Phase II, a complete technical data package (TDP) for the materials and methods used, will be developed.

Low-Cost and Rapid DNA-based Biometric Device

N10PC20104 0912007
(FY09.1 Phase II)
Low-cost and Rapid DNA Sequencer for Biometric Applications

Advanced Liquid Logic, Inc.
615 Davis Drive, Suite 800
PO Box 14025
Research Triangle Park, NC 27709-3169


Advanced Liquid Logic proposes to develop a low-cost and rapid biometric system based on DNA. Using a miniaturized DNA sequencing format the device will enable DNA-based identification of individuals as well as determination of family relationships (kinship) between individuals. The system will be implemented using Advanced Liquid Logic`s proprietary Digital Microfluidics technology, which is based on the use of electrical fields to precisely and programmably manipulate liquid droplets within a self-contained cartridge. Complex analytical procedures can be flexibly implemented as a sequence of computer-controlled droplet operations without the use of pumps or valves. Both the instrument and the disposable cartridge can be made extremely inexpensively to provide a low cost per test with minimal infrastructural investment. In the Phase I project Advanced Liquid Logic was tasked with developing detailed product requirements, evaluating the proposed technological approach and performing preliminary design and conception of the proposed product. Based on the Phase I studies, a Phase II project is proposed in which a working prototype will be delivered for evaluation by DHS. Following completion of the Phase II project a Phase III product development effort will be launched to deliver a commercial rapid DNA testing product that meets DHS`s requirements.