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Awards

Topic Information Award/Contract Number Proposal Information Company Performance
Period
Award/Contract
Value
Abstract

H-SB05.1-001
ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE

NBCHC050127 0511026
(FY05.1 Phase I)
A NOVEL METHOD FOR EFFICIENT AND SPECIFIC NULCEIC ACID ISOLATION

Cellex Inc.
9700 Great Seneca Highway
Rockville, MD 20850-3308

06/01/2005
to
12/15/2005
$100,000.00

We propose to develop a novel reagent for nucleic acid isolation. If successfully developed, this reagent will be appropriate for use in nucleic acids isolation from a variety of sample types, including environmental samples. The most advantageous characteristic of this reagent is its specific binding to nucleic acids as opposed to adsorption to solid phase, which is currently used for nucleic acid isolation. Therefore, this novel reagent is an "affinity" matrix. We expect that this reagent be appropriate for rapid nucleic acid isolation even from highly contaminated and diluted samples. In Phase I study we plan to demonstrate the feasibility of preparing this novel reagent, estimate its DNA binding capacity and evaluate its performance in terminally diluted samples. Our ultimate goal is to develop easy-to-follow protocols for both manual and automated nucleic acid isolation from a diverse sample types under a diverse conditions. This reagent also has the potential to be used for rapid and sensitive detection for microorganisms for certain samples.

H-SB05.1-006
SECURE CARTON SYSTEM

NBCHC050110 0511071
(FY05.1 Phase I)
Low-Cost Secure Carton System using Electrically Conducting Fabric

Pharad, LLC
797 Cromwell Park Drive
Suite V
Glen Burnie, MD 21061-2540

06/01/2005
to
12/15/2005
$100,000.00

Pharad proposes to design and develop technologies for the realization of a low-cost novel 'Secure Carton' which can detect tampering and physical intrusions. Our secure carton will also provide communication of the carton condition/status in real-time to the Advanced Container Security Device via an encrypted data link. The basis of our concept for a 'carton-centric' approach to intermodal container security is a secure carton which is made of an electrically conducting woven fabric or textile impregnated with a strengthening resin material that defends the physical security boundary of the carton. Any tampering activity or physical intrusion of the carton walls changes the material electrical characteristics which is detected and generates an alarm indicating that the integrity of the carton has been compromised. We will investigate suitable electrically conducting fabrics/textiles and resin materials for the physical skin of our novel secure carton. We will also develop a low-cost architecture for the tamper detection mechanism and develop the optimal electrical interconnection between the conducting fabric and the RFID tag. We will also carry out a simplified experimental proof of concept demonstration confirming the feasibility of detecting carton breaches or tampering via our novel physical electronic enclosure and tamper detection circuit.