Topic Information Award/Contract Number Proposal Information Company Performance

New System/Technologies to Detect Low Vapor Pressure Chemicals (e.g., TICs)

NBCHC040062 04110096
(FY04.1 Phase I)
Portable detector for low vapor pressure toxic chemicals

Synkera Technologies Inc.
2605 Trade Centre Ave, Suite C
Longmont, CO 80503-4605


Synkera Technologies proposes to develop an innovative new field detector for low vapor pressure toxic industrial chemicals (TICs). This detector will be based upon the integration of a unique low power pre-concentrator with an array of solid state electrochemical sensors. The solid state electrochemical sensors will be based upon the use of solid polymer electrolytes with microband electrodes. The sensor arrays will be built by a novel scalable process that results in very small, low cost and high performance sensors. These arrays of sensors will be able to detect and classify a wide range of TICs. The ultimate detector design will be focused on the development of a small, lightweight rugged and inexpensive instrument that could be used to identify low vapor pressure TICs in many diverse locations.

Chem-Bio Sensors Employing Novel Receptor Scaffolds

NBCHC040075 04110190
(FY04.1 Phase I)
Photoaptamers as Capture Reagents for Biological Agents

SomaLogic, Inc.
1745 38th Street
Boulder, CO 80301-


Antibodies are the prototypical capture reagent for biological agents (proteins and pathogens). However, despite their advantages, antibodies also have significant disadvantages with respect to shelf life, production reproducibility and, less importantly, cost. Alternative receptor scaffolds, such as nucleic acid-based photoaptamers, offer similar performance characteristics to antibodies but without the attendant drawbacks that are common to protein-based capture reagents. Furthermore, photoaptamers can detect their targets at concentrations in the low femtomolar range. SomaLogic, Inc. can design and build a simple, user-friendly, inexpensive laboratory-based analytical system that has, as its cornerstone, a photoaptamer microarray that can capture with high specificity and sensitivity the targets of interest. It will incorporate elution buffers that can be used to elute the proteins and / or pathogens of interest off of standard air filters, water filters, swabs, swipes or other sample collection devices and the necessary laboratory equipment, reagents and SOPs required for sample analysis. It will utilize standard analytical laboratory fluid handling systems for chip processing, and a standard microarray fluorescent chip reader for protein and /or pathogen detection. Finally, the entire analytical system could be assembled using existing technology within a 2-3 year time horizon.<br><br>The specific objectives of this Phase I project are:<br><br>Technical Objective #1: Demonstrate functional utility of photoaptamer arrays: dynamic range and limits of detection.<br><br>Technical Objective #2: Demonstrate superiority of photoaptamers to antibodies with respect to thermal and chemical stability.<br><br>Technical Objective #3: Demonstrate the ability to optimize specificity and affinity of our photoaptamer arrays for at least one protein target relative to other closely related proteins.<br>

Marine Asset Tag Tracking System

NBCHC040054 04110209
(FY04.1 Phase I)
Adaptation of Advanced Technology for Ordnance Surveillance to a Marine Asset Tag Tracking System

Phase IV Engineering, Inc.
2820 Wilderness Place, Suite C
Boulder, CO 80301-


In Phase I, Phase IV proposes to develop the overall architecture and design of a prototype RF system for shipping containers that will operate in the marine environment while being loaded stacked aboard ship, on board deck of a ship in a stack, unloaded, and moved and stacked in shipping terminals. Phase IV has developed a state-of-the-art RF system for tracking and monitoring munitions, both at land and at sea, for NAVSEA. The Advanced Technology Ordnance System (ATOS) includes active RF tags, fixed readers, and handheld readers. The tags have advanced power management; 4Mb of memory; IP-67 packaging (capable of immersion in water for 30 minutes); temperature, humidity, and shock sensing; and programmable alerts. The fixed readers have Ethernet interfaces and can be daisy chained to cover a wide perimeter. The handheld readers are derivatives of a COTS Pocket PC data collection device. Phase IV has also developed the Barrier Communication System (BCS) for wireless transmission through metal container walls. Phase IV proposes to adapt and commercialize the ATOS and BCS technology for a production marine asset tag tracking system. Phase IV is prepared to demonstrate the ATOS and BCS system to HSARPA upon request.