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Abstracts of FY05.1 Phase I Awards
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H-SB05.1-001

Company

Cellex Inc.
9700 Great Seneca Highway
Rockville, MD 20850-3308

Proposal Information 0511026 - A NOVEL METHOD FOR EFFICIENT AND SPECIFIC NULCEIC ACID ISOLATION
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050127
Abstract

We propose to develop a novel reagent for nucleic acid isolation. If successfully developed, this reagent will be appropriate for use in nucleic acids isolation from a variety of sample types, including environmental samples. The most advantageous characteristic of this reagent is its specific binding to nucleic acids as opposed to adsorption to solid phase, which is currently used for nucleic acid isolation. Therefore, this novel reagent is an "affinity" matrix. We expect that this reagent be appropriate for rapid nucleic acid isolation even from highly contaminated and diluted samples. In Phase I study we plan to demonstrate the feasibility of preparing this novel reagent, estimate its DNA binding capacity and evaluate its performance in terminally diluted samples. Our ultimate goal is to develop easy-to-follow protocols for both manual and automated nucleic acid isolation from a diverse sample types under a diverse conditions. This reagent also has the potential to be used for rapid and sensitive detection for microorganisms for certain samples.

Company

CFD Research Corporation
215 Wynn Dr.
5th Floor
Huntsville, AL 35805-1926

Proposal Information 0511082 - A Novel Electrokinetics-Driven, Integrated Microfluidic Cartridge for Sample Preparation from Complex Matrices
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050114
Abstract

Sample preparation has been recognized as the single most important challenge to be faced in the development of detect-to-warn (DTW) systems (NRC, 2005). Available commercial sample preparation technologies are expensive, slow (30 min to 2 hours) and require trained laboratory technicians for operation. Addressing this need, we propose to design, fabricate, and demonstrate a novel integrated microfluidic cartridge exploiting advanced electrokinetics for preparation of complex liquid samples for genomic analysis. Building on CFDRC's expertise and proprietary platform in Phase I, we will demonstrate separation of bacterial cells from a contaminant-laden solution, followed by reagent-less lysis to extract the genomic content. Device designs will be guided by proven high-fidelity simulation methods developed by CFDRC. The microfabricated components will be tested and demonstrated in our well-equipped microfluidics laboratory. In Phase II, an integrated microfluidics sample preparation cartridge will be developed for ready interfacing with existing/next-generation detection technologies. The integrated cartridge will consist of separation, lysis, purification, pre-concentration and COTS components. Phase II prototype will be extensively demonstrated and characterized for samples containing various genomic targets in the presence of common atmospheric background (dust, pollen, etc.)

Company

American Research Corporation of Virginia
1509 Fourth Street
P.O. Box 3406
Radford, VA 24143-3406

Proposal Information 0511129 - Electrostatic-magnetostatic Separation of Biological Samples During Electrospray Processing
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050115
Abstract

Recent events showing the willingness of terrorist organizations and rogue states to consider biological weapons of mass destruction have underscored the need for rapid means to identify these agents. In particular, first responders entering a scene where biological agents may have been dispersed must have the tools necessary to characterize bioweapons in aerosols and in complex liquid or solid matrices. Existing rapid methods of bioanalysis relying upon polymerase chain reaction (PCR), gene chips, and protein and antibody arrays require substantial sample preparation to provide consistent results in the face of interferences, contaminants and inhibitors that are present in ambient air and water and samples eluted from solid surfaces. This proposal suggests the use of atmospheric electrospray ionization in conjunction with nanoparticle enhancement of separation efficiency as a means of high-throughput sample preparation. The innovation of the proposed biological sample processing system is the combination of electrospray ionization in the presence of functionalized nanoparticles with downstream magnetic charge-based and mass-based separation to provide selective concentration and purification of biological materials. The Phase I Technical Objectives include design and fabrication of a laboratory electrospray processing system having downstream electrostatic and magnetostatic separation, evaluation of the effect of magnetic and high-charge density nanoparticle additives on the efficiency of biomolecule purification and concentration, and acquisition of families of test data using simulated biological samples for use in optimization of a proof-of-concept prototype system. In Phase II, test procedures will be automated and miniaturized for further development in the Phase III commercialization segment of the program. Successful completion of the Phase I program will result in the demonstration of electrospray techniques for processing biological samples from various matrices. The processing system will find commercial use in biomedical evaluation of infectious diseases, environmental chemical analysis and food processing.

Company

Chembionics, Inc.
7915 Silverton Avenue, Suite 307
San Diego, CA 92126-6348

Proposal Information 0511164 - A NEW METHOD FOR SAMPLE PREPARATION DIRECTLY IN AEROSOLS
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050122
Abstract

Rapid detection of pathogens in air and/or liquid samples is of paramount importance to minimize a potential threat of biological warfare agent attack as well appearance of emerging infectious diseases. Current methods, particularly those that target aerosols are determined by the efficiency and speed of sample preparation which comprises collection of air sample its conversion into a liquid sample and specific detection of pathogens using immuno-based method or those that rely on detection of nucleic acids characteristic for each pathogen. This project concerns a development of an innovative approach to separation of microorganisms in (bio)aerosols where the identification is performed directly in the gas-phase. The methodology is based on the ability to control and monitor the occurrence of biochemical reactions directly in air which enables recognition of pathogens through their specific surface markers or even using their characteristic gene sequences. The Phase I project will demonstrate feasibility of specific binding and separation of simulant microorganisms in air. The proposed sample preparation technology has a potential to be implemented in many different assay schemes which could include both air and liquid samples. Competitive advantages of this technology include: (i) direct and pathogen specific detection in air; (ii) detection time approaching near-real time monitoring; (iii) high sensitivity; and, (iv) low false positives.

Company

AnzenBio, LLC
2475 West California Avenue
Salt Lake City, UT 84104-1516

Proposal Information 0511190 - Integrted Molecular Assay System
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050121
Abstract

This Phase I proposal seeks to develop and demonstrate an improved first responder molecular analysis system based on a simplified methodology using aluminum oxide membrane (AOM) integrated sample preparation, amplification, and detection technology. This method has been shown to be faster, simpler, less expensive and more sensitive than existing methods. This proposal seeks to extend the applicability of this method to biodefense/ environmental contamination applications for simplified molecular analysis of relevant samples applicable to first responder settings. Phase I will broadly demonstrate the advantages of the proposed method by direct comparison to currently used sample preparation, amplification, and detection methods based on speed, sensitivity, complexity, and cost for analysis. Phase I Technical Objectives include demonstrating applicability of the AOM method for use with currently used pathogen harvesting methods from gas, liquid, and solid samples, investigation of relevant pathogen lysis conditions, investigation of RT-PCR detection of pathogen derived localized nucleic acids by the AOM method, direct comparison of the AOM method with conventional methods, and generation of Preliminary Specifications for an improved first responder molecular analysis system to be developed in a Phase II proposal. Phase II will lead to commercialization of a next generation first responder molecular analysis system.

Company

Core MicroSolutions Inc.
1100 Glendon Avenue 17th Floor
Los Angeles, CA 90024-3588

Proposal Information 0511198 - Channel to Droplet Sample Extraction and Purification Using Electrowetting Device
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050123
Abstract

To develop advanced "channel-to-droplet" sample extraction and purification functions on a compact cartridge that is free of sensitive and complex microfluidic components, Core Microsolutions (CMSS) and Professor Sung Cho of the University of Pittsburgh propose to integrate Electrowetting-on-Dielectric (EWOD) droplet handling and in-droplet concentration capabilties with well proven channel-based separation methods to: a) separate target particles, b) extract the concentrated target particles in a mobile droplet, c) bifurcate the particle mix within the droplet using Dielectrophoretic separation methods for a 2nd level of concentration effects, and then d) drive the target-rich droplet to a sensing point or pipette extraction site. This proposed DHS work will develop the sample extraction and purification methods needed to complement CMSS' ongoing two year $1M NIH Biodefense Phase I grant that will produce the hardware and driving systems needed for novel bacteria immuno-capture and transduction on an EWOD sensing cartridge. This hybridization of channel and droplet-based sample handling on a generic slide cartridge will enable elegant transfer of channel-based separation products to an array of electronic, optical, surface plasmon resonance (SPR), mass spectrometry (MS) instrumentation. Comparisons in cost/performance will be made against existing methods at the end of Phase I.

Company

Microchip Biotechnologies Inc
4059 Clipper Court
Fremont, CA 94538-6540

Proposal Information 0511225 - Development of an advanced fluidic sample bioprocessor
Topic Information H-SB05.1-001 - ADVANCED SAMPLE PROCESSING OF LIQUID, OR SOLID OR AEROSOL SAMPLES, OR A COMBINATION OF TWO OR THREE
Award/Contract Number NBCHC050133
Abstract

This proposal describes a completely automated, NanoBioSentinel sample preparation instrument for biodefense. The NanoBioSentinel will contain two modules: a bead-based Sample Capture and Purification Module (SCPM) front-end and a microchip-based NanoBioProcessor Module. Built partly upon existing devices, the SCPM will use immunocapture and multi-dimensional purifications to process milliliter volumes into microliter volumes. Target organisms and agents are captured, concentrated, and purified on antibody-conjugated beads before lysis followed by bead-based nucleic acid binding and purification in the SCPM. Purified samples on beads are then moved into the NanoBioProcessor Module for fluidic sample processing in a microchip format. The NanoBioProcessor microchips have simple on-chip valves, pumps, and routers and can perform most chemistries. In Phase I, the sample preparation method to be evaluated will be sample preparation for a two-dimensional detection: (1) microscale-Real Time-PCR and (2) microchannel capillary array electrophoresis fragment sizing for confirmation of positives. While we develop the "backend" targeting these chemistries, the NanoBioSentinel will be able perform most chemistries and feed most analytical platforms. The technology will be the basis of sample preparation and analysis systems for pathogen detection, diagnostics and biodefense.

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H-SB05.1-002

Company

Radiation Monitoring Devices, Inc.
44 Hunt Street
Watertown, MA 02472-4699

Proposal Information 0511036 - IMPROVED SPECTROSCOPIC GAMMA RAY DETECTORS
Topic Information H-SB05.1-002 - IMPROVED SPECTROSCOPIC GAMMA RAY DETECTORS
Award/Contract Number NBCHC050130
Abstract

Spread of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of radioactive materials and nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. Gamma ray spectrometers are an important tool in homeland defense and monitoring to check the spread of special nuclear materials (such as highly enriched uranium and weapons grade plutonium) and nuclear weapons. An important challenge in homeland security monitoring is not only to detect hidden radioactive materials but also to distinguish them from routinely used radiopharmaceuticals as well as naturally radioactive materials [McDonald]. A number of homeland security systems such as hand-held radioisotope identifiers, vehicle portals for radiation detection and personal radiation detection devices rely on availability of high performance gamma-ray spectrometers. Important requirements for the gamma ray spectrometers used in these applications include good energy resolution, high detection efficiency, compact size, light weight, easy portability and low power consumption. None of the available gamma-ray sensors satisfy all these requirements. The goal of the proposed effort is to investigate new scintillators that appear to be very promising for this vital application.

Company

Physical Optics Corporation
20600 Gramercy Place, Building 100
Torrance, CA 90501-1821

Proposal Information 0511064 - Novel Quantum Dot Assisted Semiconductor Gamma Ray Detector
Topic Information H-SB05.1-002 - IMPROVED SPECTROSCOPIC GAMMA RAY DETECTORS
Award/Contract Number NBCHC050112
Abstract

To address homeland security needs, Physical Optics Corporation (POC) proposes to develop a new Gamma Ray Quantum Dot Semiconductor Heterostructure (GammaDot) sensor system. This compact modular system consists of Pb quantum dot (Q-dot) heterostructure laser module, a photodiode module, and a smart electronics module. The Pb Q-dot laser module consists of a stack of heterostructure lasers, which generates a laser output proportional to the incident gamma ray photons captured by Pb atoms. The photodiode module detects this output, and the detected signals are processed and interpreted by the smart electronics module to extract gamma ray spectral data. The GammaDot sensor system will have excellent energy resolution of <0.1% of FWHM, far superior to other detector technologies. The multilayer design enables the GammaDot sensor system to scan a high-energy bandwidth of 20 keV to 3 meV with 90% of the efficiency of the NaI crystal standard. Room-temperature operation and the low operating power of the components result in a low system power consumption of <0.5 W. Mass manufacturing will produce a system that is volume-priced at a few hundred dollars. In Phase I POC will demonstrate the feasibility of the concept by building and testing a proof-of-concept GammaDot sensor. In Phase II POC plans to develop a fully functional prototype that will be integrated with a power supply and data acquisition system. When completed, the entire system could be functionalized into an inexpensive handheld gamma ray spectrometer or adapted into an array system for imaging - including baggage and cargo screening. GammaDot sensors can be adapted for detecting and imaging X-rays for biomedical applications. Because they can be pixilated and produced at ultralow cost, we foresee a large demand for these novel devices. Traditional high energy and nuclear physics experimental efforts could benefit from the compactness and position resolution of GammaDot sensor arrays. The unique arrangement of sensors in the system ensures unprecedented resolution and sensitivity over a wide energy bandwidth.

Company

Radiation Monitoring Devices, Inc.
44 Hunt Street
Watertown, MA 02472-4699

Proposal Information 0511094 - High Efficiency, Room Temperature Semiconductor Detectors
Topic Information H-SB05.1-002 - IMPROVED SPECTROSCOPIC GAMMA RAY DETECTORS
Award/Contract Number NBCHC050129
Abstract

Prevention of the spread of nuclear weapons has reached a state of heightened urgency since the events on September 11, 2001. Gamma ray spectrometers are important tools in homeland security to check the spread of nuclear materials and weapons. Important requirements for gamma ray spectrometers used in this application include good energy resolution, high detection efficiency, compact size, light weight, easy portability and low power consumption. None of the currently available detectors meet all of these requirements. In the proposed effort, we plan to explore a wide bandgap semiconductor material, thallium bromide (TlBr), as a room temperature detector for nuclear monitoring. TlBr has high density (7.5 g/cm3) and atomic number constituents for high gamma ray stopping power, and high resistivity (>1010 W-cm) for low noise device operation. Furthermore, the material melts congruently at a modest temperature (480 degree C), which allows use of melt-based crystal growth approaches to produce large volume crystals. Recent results indicate that through sufficient material purification, charge transport properties approaching those of CZT can be achieved. The goal of the proposed project is to perform rigorous investigation of purification and crystal growth of this promising material to produce high performance TlBr gamma-ray spectrometers for homeland security.

Company

Sentor Technologies Inc.
11551Q Nuckols Rd
Glen Allen, VA 23059-5565

Proposal Information 0511098 - A Spintronic Room Temperature High Purity Germanium Gamma Radiation Spectrometer
Topic Information H-SB05.1-002 - IMPROVED SPECTROSCOPIC GAMMA RAY DETECTORS
Award/Contract Number NBCHC050131
Abstract

Recent breakthroughs in the emerging field of spintronics (short for spin-based electronics) suggest that it may be possible to develop a high purity germanium detector that operates at room temperature. This tantalizing possibility is due to the discovery that the resistance of a semiconductor device with anti-aligned spintronic front and back contacts is independent of the intrinsic carrier concentration and depends only on the alignment and polarization of the contacts. The objective of the proposed research program is to develop and demonstrate the world's first spintronic gamma-ray spectrometer. If successful, the proposed spintronic HPGe detector has the potential to provide a room temperature energy resolution far surpassing any existing instrument.

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H-SB05.1-003

Company

Atlas Scientific
1367 Camino Robles Way
San Jose, CA 95120-4925

Proposal Information 0511043 - Miniature Long-Life Cooler for Portable Gamma Ray Detectors
Topic Information H-SB05.1-003 - IMPROVED HIGH PURITY GERMANIUM COOLING MECHANISMS
Award/Contract Number NBCHC050120
Abstract

This proposal describes a battery operated cryocooler to be used for cooling High Purity Germanium (HPGe) detectors, commonly used for the detection of gamma rays. HPGe detectors are highly suitable for identifying nuclear materials, which is of great interest in the Department of Homeland Security (DHS) applications. HPGe detectors need to operate near 110 K requiring refrigeration for portable HPGe detectors. Portability is highly desirable and can be accomplished by means of a standalone, compact, low-vibration, efficient cryocooler. Power consumption is to be sufficiently low so that the overall system including battery packs is indeed portable. Various existing cryogenic refrigeration systems are thought not to be applicable for the current DHS application either for reasons of excessive power consumption, vibration or system mass, or for lacking reliability and efficiency. To address the refrigeration issue, we propose to develop a miniature pulse tube cooler. High frequency, pulse-tube coolers (PTCs) represent the most promising technology for achieving lightweight standalone cryocoolers. Applications of this cooler include cooling of infrared and gamma ray detectors, cooling of electronics, and for use in the biomedical industry.

Company

Creare LLC
P.O. Box 71,
16 Great Hollow Road
Hanover, NH 03755-0071

Proposal Information 0511070 - Miniature, Efficient, Low-Vibration Cryocooler for Gamma Ray Detectors
Topic Information H-SB05.1-003 - IMPROVED HIGH PURITY GERMANIUM COOLING MECHANISMS
Award/Contract Number NBCHC050128
Abstract

Hand-held gamma ray spectrometers are a vital tool for detecting and identifying nuclear materials to counter the threat of radiological and nuclear terrorism. The HPGe crystals in these detectors must operate at cryogenic temperatures to achieve good energy resolution. We propose to develop an innovative, miniature cryogenic cooling system that will be ideal for hand-held detectors. High efficiency will enable long battery life, and low vibration will improve the detector sensitivity. In addition, the system will be lightweight and inexpensive to produce. In Phase I, we will prove the feasibility of our approach by building and demonstrating critical components and producing a conceptual design for a prototype cryocooler. In Phase II, we will build and demonstrate a complete prototype system. Homeland security applications include nuclear materials interdiction, safeguards inspection, and emergency response. The cooler can also be used to cool portable x-ray detectors and infrared sensors used in military targeting and guidance systems. The commercial nuclear industry can use the cooler/detector for in-situ waste assay measurements, nuclear reactor maintenance, and health physics.

Company

Atlas Scientific
1367 Camino Robles Way
San Jose, CA 95120-4925

Proposal Information 0511114 - High Performance Long-Life Cooler for Transportable Gamma Ray Detectors
Topic Information H-SB05.1-003 - IMPROVED HIGH PURITY GERMANIUM COOLING MECHANISMS
Award/Contract Number NBCHC050113
Abstract

This proposal describes a transportable cryocooler to be used for cooling High Purity Germanium (HPGe) detectors, commonly used for the detection of gamma rays. HPGe detectors are highly suitable for identifying nuclear materials, which is of great interest in the Department of Homeland Security (DHS) applications. HPGe detectors need to operate near 110 K requiring refrigeration. High cooling performance is highly desirable and can be accomplished by means of a compact, low-vibration, efficient cryocooler. Various existing cryogenic refrigeration systems are thought not to be applicable for the current DHS application either for reasons of excessive vibration or system mass, or for lacking reliability and efficiency. To address these refrigeration issues, we propose to develop a high performance pulse tube cooler. High frequency pulse-tube coolers (PTCs) represent the most promising technology for achieving reliable lightweight cryocoolers. Applications of this cooler include cooling of infrared and gamma ray detectors, cooling of electronics, and the biomedical industry.

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H-SB05.1-004

Company

FarSounder, Inc.
43 Jefferson Blvd.
Warwick, RI 02888-1078

Proposal Information 0511067 - Low Cost 3D Sonar System for Underwater Threat Detection
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050132
Abstract

FarSounder proposes to develop a low cost 3D sonar system for underwater threat detection. This system will be based on the FarSounder 3D sonar technology and will utilize COTS components which will leverage FarSounder`s advanced processing techniques to increase the system`s performance when compared to currently available port security sonars. For this Phase I effort FarSounder will perform a feasibility study and develop a concept design for the 3D Underwater Threat system. Phase II will deliver a prototype low cost, low power, small size system for incorporation into a multi-faceted Port Security System. The ultimate commercialized system will be easy to use, easy to deploy, have a low false alarm and fall within the goal of less than $100K per 1000 feet of protected asset. The system will have the ability to detect open circuit divers, closed circuit divers, divers with propulsion assistance and underwater vehicles that approach or enter the security zone and provide an alert to a central station or system operator. FarSounder`s solution will have a high probability of detection of real underwater threats and a low false alarm rate for these targets. Through simulation, field testing with existing hardware and acoustic modeling, FarSounder will validate the key elements of the design. Phase I objectives are to develop a solution concept with effective performance and end usability in mind; demonstrate that shallow water detection of targets in 3D is possible; demonstrate that detection of swimmer size targets is possible with FarSounder`s 3D approach; study feasibility of target classification and identification; and develop a hardware architecture that utilizes all COTS components to ensure affordable future product costs. Benefits include increased protection of ports, critical waterside infrastructures and other fixed shoreline sites and prevention of attacks affecting large areas of local populations such as those near LNG terminals. The system will provide the first underwater port security system practical for use in all US ports and along extensive areas of US coastlines and inland waterways. Spinoff commercial applications include a solution for the protection of endangered marine mammals, by enabling effective localization, identification and avoidance of these mammals; a cost efficient localization and identification sonar appropriate for the $3.2B annual US fisheries industry to reduce by-catch; and a low-cost on-board security sonar system for commercial cargo ships, oil tankers, passenger vessels and large recreational boats. "For any purpose other than to evaluate the proposal, this data except proposal cover sheet shall not be disclosed outside the Government and shall not be duplicated, used, or disclosed in whole or in part, provided that if a contract is awarded to the proposer as a result of or in connection with the submission of this data, the Government shall have the right to duplicate, use or disclose the data to the extent provided in the funding agreement. This restriction does not limit the Government`s right to use information contained in the data if it is obtained from another source without restriction. The data subject to this restriction is contained on the pages of the proposal listed on the line below."

Company

Scientific Solutions, Inc.
99 Perimeter Road
Nashua, NH 03063-1325

Proposal Information 0511093 - COST-SAVING ENHANCEMENTS TO THE SWIMMER DETECTION SONAR NETWORK (SDSN)
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050126
Abstract

A low cost Swimmer Detection Sonar Network (SDSN) is now being developed under an ONR Phase 2 SBIR and as a joint project between the USA and Singapore. The SDSN is a network of inexpensive sonar nodes where narrow sonar beams are formed using air-backed parabolic reflectors. The feasibility of the system has been proven through trials conducted in Singapore harbor and full development is well underway. Currently each parabolic reflector has a single transducer at the focal point and is used for both transmission and reception. There is one parabolic reflector for each beam, with up to 10 beams per node. A substantially less complex, cheaper, and smaller node might be realized using a single wide-beam transmitter and a multi-beam air-backed spherical reflector receiver. Initial modeling shows promise. The Phase 1 effort would include more thorough modeling, testing of a multi-beam air-backed spherical reflector receiver, and design of a complete node. In Phase 2 we would build up 3 nodes and evaluate their performance against the current design. If successful this SBIR would make the SDSN even more cost effective, allowing for its use in a much broader range of applications, along with significantly increasing the commercial potential.

Company

Alaska Native Technologies, LLC
5631 Silverado Way
Suite F
Anchorage, AK 99518-1651

Proposal Information 0511119 - Swimmer Detection
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050118
Abstract

The United States Coast Guard`s homeland security mission includes providing security for 361 ports and 95,000 miles of US Coastline. This coastline is susceptible to both criminal and terrorist attack. Waterside facilities and critical infrastructure are especially vulnerable to attack from on or under water. Alaska Native Technologies, LLC (ANT) propose using broadband active sonar technology coupled with artificial neural networks to provide critical swimmer detection capability at less than $100,000 per 1000 lineal feet of shoreline. A brief feasibility study with a system designed for fish identification performed for the US Navy in 2003 resulted in an 86% swimmer detection rate and a 94% non-swimmer identification rate.

Company

Acoustech Corporation
Philadelphia Naval Business Center
4900 South Broad Street, Building 6, Suite LL00
Philadelphia, PA 19112-1302

Proposal Information 0511121 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050146
Abstract

Acoustech Corporation (Acoustech), Applied Physical Sciences Corporation (APS), and Navmar Applied Sciences Corporation (Navmar) have teamed to develop a low cost underwater detection system that will protect assets located along the shoreline from domestic and foreign terrorists. Acoustech will be responsible for overall project management and underwater transducer development, APS will be responsible for detection system algorithm development, and Navmar will be responsible for system integration. The detection system combines Navmar`s Modular Intelligent Surveillance Tool (MIST), a passive optical/thermal surveillance system, with a multistatic sonar, and an acoustic trip-wire to detect and track terrorists that are approaching a shoreline asset. The Phase I effort is centered on developing the receive transducers and detection algorithms for the multistatic sonar system. These technologies will then be used to perform an experiment to determine the location of a stationary target in a controlled laboratory environment. The target will be representative of a diver that is equipped with and without a scuba tank so the difference in target-strength can be investigated for open- and closed-circuit divers. Other aspects of the Phase I effort concern the technical innovation required to integrate of the acoustic systems into MIST and the development of a comprehensive commercialization plan.

Company

Intelligent Optical Systems, Inc.
2520 W. 237th Street
Torrance, CA 90505-5217

Proposal Information 0511138 - High Resolution Underwater Passive Threat Detection System
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050124
Abstract

We propose to develop a highly sensitive, low cost system for underwater perimeter control. The setup, designed for protection of waterside facilities and infrastructure, consists of a fiber-optic cable placed in front of a critical or high-value asset, connected to a compact readout system. A single source sends out acoustic sonar pulses. Sensor structures embedded in the fiber in conjunction with innovative mechanical features and a novel readout system form an ultra-sensitive distributed detector for backreflections of any approaching object. A sophisticated data processing algorithm reconstructs the features of the possible intruder, compares it to its decision table and triggers an alarm if indicated. Built-in temperature compensation and self-referencing will allow reliable measurements in diverse environmental conditions. In Phase I, IOS will develop a working model of the sensing array and deliver it to HSARPA for demonstration. A fully functional prototype will be developed and demonstrated in Phase II.

Company

Advanced Acoustic Concepts, Inc.
425 Oser Avenue
Hauppauge, NY 11788-3640

Proposal Information 0511181 - Advanced Acoustic Intercept Array for Underwater Surveillance and Threat Detection
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050107
Abstract

Protection of the Homeland must include the monitoring of our airspace, borders, and most importantly, shorelines. Securing our waterside assets is a difficult task that must utilize a multi-sensor surveillance system that requires a reliable underwater threat detection sensor. AAC produces for the Navy a state-of-the-art underwater acoustic sensor array that is ideal for this purpose. During Phase I, AAC will evaluate the sensor's performance in a noisy port environment and use this data to predict the performance of the Advanced Acoustic Intercept array being developed for the next generation Navy anti-torpedo system. Together with our signal processing software, which includes advanced classification algorithms currently in development, this system will provide the necessary detection capabilities, cost per unit length of protected asset, and low false alarm rate to be a viable threat detection tool. The commercial applications of an underwater threat detection system include protection of various industrial shoreline facilities such as power plants, oil repositories, etc. Since the array is easily deployable, this system is also applicable to in-harbor ship protection for Navy/Coast Guard ships as well as cargo ships, oil tankers, barges, and cruise ships. The system may also be of interest to the fishing industry.

Company

Toyon Research Corporation
6800 Cortona Drive
Goleta, CA 93117-3021

Proposal Information 0511211 - An Underwater Threat Detection System Employing Low-Cost Sensing and Advanced Algorithms
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050134
Abstract

A vast array of high-value installations are situated within or near waterways. With such a large number of vulnerable targets, current threat detection schemes are too costly to provide sufficient levels of protection. At the same time, with 95% of material goods arriving via ports and waterways, any new system must offer sufficient performance to prove effective in such an active environment. A new paradigm in identification and localization of targets of interest is the use of large numbers of low-cost distributed sensors rather than single high-fidelity sensors. This proposal seeks to provide an autonomous system that mates arrays of underwater transducers to novel fusion, tracking, and target classification algorithms. Our sensing approach is based on the concept of active forward scattering. Sets of measurements from the sensor array are passed to a central control center, which can be located on- or off-site and uses COTS computer hardware. The particle filter will be used for fusion and tracking due to the ease with which it can manage nonlinear measurements and negative information. A Bayesian network will be used for target classification because the algorithm can incorporate an array of target attributes including signature, velocity, bearing, maneuverability, etc.

Company

BioSonics, Inc.
4027 Leary Way NW
Seattle, WA 98107-5045

Proposal Information 0511262 - The BioSonics UnderWater ACoustic Sentinel (UWACS), a Low Cost Underwater Threat Detection System
Topic Information H-SB05.1-004 - LOW COST UNDERWATER THREAT DETECTION SYSTEM
Award/Contract Number NBCHC050125
Abstract

The purpose of this project is to develop and demonstrate the feasibility of a concept design for a low cost underwater threat detection system to protect critical shoreline and waterside infrastructure. For 26 years, BioSonics has designed and manufactured state-of-the-art digital scientific echosounder technologies for real-time detection, tracking, and classification of biological targets in hostile, cluttered and boundary environments. BioSonics has demonstrated that our low cost, portable COTS echosounder system is well-suited for the unique challenges of threat detection, classification, and early warning in the land-water interface. In Phase I, BioSonics will evaluate, improve and demonstrate COTS hardware, software and positioning system components for effectiveness in threat detection. Proven detection capabilities will be adapted to larger targets such as divers and submersibles in a variety of environments to establish range and boundary performance and to test classification and alarm algorithms. The BioSonics solution utilizes an active hydroacoustic system consisting of a networked series of focused beam transducers with ultra low side lobes, mounted on robust, dual-axis rotators, capable of sufficient detection range, high detection probability and low false alarm rates. The commercialization potential of this low cost, effective product for homeland security, defense, public and private sector markets is tremendous.

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H-SB05.1-005

Company

Physical Optics Corporation
20600 Gramercy Place, Building 100
Torrance, CA 90501-1821

Proposal Information 0511073 - Inertial Capacitive Incapacitator
Topic Information H-SB05.1-005 - INNOVATIVE LESS-LETHAL DEVICES FOR LAW ENFORCEMENT
Award/Contract Number NBCHC050108
Abstract

The Homeland Security Advanced Research Projects Agency is seeking an innovative less-lethal untethered electromuscular disruptor device that is inexpensive, safe, lightweight, man portable, and easy to use to stop illegal behavior of individuals, groups, or crowds. The physical environments vary from a small room to a city street or a sports stadium. The goal is to temporarily incapacitate, confuse, delay, or restrain a person or persons when lethal force is not appropriate or the use of lethal force could cause collateral effects such as injury to bystanders, or damage to property or the environment. To meet this need, Physical Optics Corporation (POC) proposes to develop a new Inertial Capacitive Incapacitator (ICI) based on a unique combination of a soft ring airfoil with a compact, thin film voltage generator. The ICI will be powered by inertial force to produce a high-voltage discharge of limited energy. The ICI device can be optimized to fit virtually any launcher. Because of the low impact momentum needed, the ICI is safe and can be launched even by a pneumatic pistol. The ICI is charged when it is fabricated, and can maintain this charge for decades. The electric energy delivered does not depend on the distance to the target. The proposed ICI avoids the drawbacks of current nonlethal munitions: it is not tethered to the launching platform, and is low-cost, lightweight, and easy to use. Commercial products will include modified nonlethal tools and weapons for law enforcement, security guards, personal self-defense, and possibly hunting. With their single stun dartless action, the novel ICI based projectiles will dramatically reduce the risk of accidental lethal injury, and can replace present nonlethal weapons. The ICI technology will replace blunt trauma with much safer electrical incapacitation.

Company

Mide Technology Corporation
200 Boston Avenue Suite 1000
Medford, MA 02155-4242

Proposal Information 0511108 - Untethered Electro-Muscular Disruption Device
Topic Information H-SB05.1-005 - INNOVATIVE LESS-LETHAL DEVICES FOR LAW ENFORCEMENT
Award/Contract Number NBCHC050106
Abstract

Mide, along with ballistics and firearms expert Ed Hartwell, proposes development of the "Piezer" (pee-ay'-zer) - an untethered electro-muscular disruption non-lethal stun weapon based on piezoelectric technology for civil law enforcement officers and the military. The innovative new device would provide individual threat control at increased range (40 - 50 meters) over existing weapons and compatibility with 12 gauge shotguns. Piezoelectrics enable efficient high voltage generation in a small package, and can be designed to deliver high-energy stun pulses. The Piezer device combines the proven effectiveness, legal and social acceptability of the Taser(R) with the ease of use, practicality, and extended range of shotgun shells. Utility of the Piezer is probably best realized in crowd control situations or riots having high levels of aggression. These situations meet the requirement that an additional lethal weapon must be trained on an individual or group before a non-lethal weapon can be used. This rule is common to domestic law enforcement groups.

Company

Intelligent Optical Systems, Inc.
2520 W. 237th Street
Torrance, CA 90505-5217

Proposal Information 0511135 - Less-Lethal Eye Safe Handheld LED-Based Incapacitator for Law Enforcement
Topic Information H-SB05.1-005 - INNOVATIVE LESS-LETHAL DEVICES FOR LAW ENFORCEMENT
Award/Contract Number NBCHC050104
Abstract

Intelligent Optical Systems (IOS) has developed and demonstrated a prototype dazzler that utilizes an array of super-bright Light Emitting Diode (LED) clusters to produce disorientation and strong flashblindness with afterimages. In this project, IOS proposes to develop a significantly improved device that can operate at distances up to 50 feet at the maximum permissible eye-safe level. Two new innovations will be incorporated into the device: (1) a rangefinding technology that will permit rapid adjustment of the radiant power to the maximum eye-safe level, in real time, at any of the operational target distances; and (2) a novel scanner that will allow the device to cover an area much larger than the beam size, while still providing a flash frequency and exposure level as effective as the single beam over the entire area. Control electronics and a preprogrammed chip will be used to allow operation at randomly varying frequencies within the band of maximum effectiveness, and to utilize several colors of light to enhance disorientation.

Company

UHV Technologies, Inc.
450 South Freeway
Fort Worth, TX 76104-3503

Proposal Information 0511160 - Innovative Electrostatic Energy Projectile Technology
Topic Information H-SB05.1-005 - INNOVATIVE LESS-LETHAL DEVICES FOR LAW ENFORCEMENT
Award/Contract Number NBCHC050117
Abstract

In this SBIR Phase I project, we will demonstrate the feasibility of an innovative electrostatic projectile technology that will enable development of non-lethal untethered electro-muscular disruptor devices. These low cost projectiles will be potentially used with a grenade launcher or a shotgun, commonly used by law enforcement personnel. During the Phase I, a prototype setup will be built to evaluate the salient features of this technology and the potential range of these projectiles will be calculated. The applicability of this technology to individuals, groups, crowds and machinery will be evaluated. In addition, environmental effects and collateral effects will also be investigated. In a follow-on Phase II project, we will design, build and test two prototype devices in two public safety scenarios.

Company

Lynntech, Inc.
2501 Earl Rudder Freeway South
College Station, TX 77845-6023

Proposal Information 0511192 - A Non-Lethal, Non-Tethered, Inexpensive Electro-Muscular Disruption Projectile
Topic Information H-SB05.1-005 - INNOVATIVE LESS-LETHAL DEVICES FOR LAW ENFORCEMENT
Award/Contract Number NBCHC050116
Abstract

Recent trends in law enforcement clearly illustrate the effectiveness of the taser to debilitate even the toughest targets, without causing permanent injury or lingering after-effects. Current electric stun technology is either hand-held or short-range and tethered to the launch platform. The law enforcement agencies would greatly benefit from a longer range (6 to 40 meters), non-tethered electric stun projectile. The introduction of tasers caused sharp decreases in injuries to both police officers and suspects. It is expected that a longer range device would provide the same results. Lynntech proposes to design, fabricate, and test a non-lethal, non-tethered, electro-muscular disruption (EMD) projectile for a 40mm grenade launcher. A standard 12 gauge shotgun cartridge will be developed during the Phase II effort. The projectile will not require modification to the launch platform, will include wireless activated follow-up EMD capability, and will not be enabled until after the projectile has been launched. These features will ensure user safety before, during, and after firing and will allow for administration of additional doses to the target as required. Potential applications include the military and law enforcement agencies throughout the world, security personnel at airports, banks, private organizations, and everyday citizens seeking personal and property protection.

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H-SB05.1-006

Company

Essential Systems Integration, Inc.
13506 Thrush Street NW
Andover, MN 55304-3390

Proposal Information 0511031 - Secure Carton System by ESII
Topic Information H-SB05.1-006 - SECURE CARTON SYSTEM
Award/Contract Number NBCHC050119
Abstract

Essential Systems Integration, Inc (ESII) proposes to fulfill the objective of developing a sub-system device for securing cargo that communicates to the Advanced Container Security Device (ACSD). Multiple technologies are employed to accommodate securing various package sizes and to indicate a breach in the cargo. Anti-bypass methods and encryption techniques are implemented to ensure cargo integrity. The device can be tracked and have other detection devices incorporated. It is complementary to the Marine Asset Tag Tracking System (MATTS) communication hardware. The ESII patent pending device has commercialization potential in nearly every market where securing and tracking items is vital, because it can communicate to industry standard equipment. Legend: For any purpose other than to evaluate the proposal, this data except proposal cover sheet shall not be disclosed outside the Government and shall not be duplicated, used, or disclosed in whole or in part, provided that if a contract is awarded to the proposer as a result of or in connection with the submission of this data, the Government shall have the right to duplicate, use or disclose the data to the extent provided in the funding agreement. This restriction does not limit the Government`s right to use information contained in the data if it is obtained from another source without restriction. The data subject to this restriction is contained on the pages of the proposal listed on the line below.

Company

Physical Optics Corporation
20600 Gramercy Place, Building 100
Torrance, CA 90501-1821

Proposal Information 0511032 - Secure Carton Integrated Electronic Remote System
Topic Information H-SB05.1-006 - SECURE CARTON SYSTEM
Award/Contract Number NBCHC050111
Abstract

The Department of Homeland Security is seeking innovative approaches and key technologies for securing intermodal cargo, and for integrity monitoring with tracking capability at the level below that of the ISO container. This technology is to include a secure tamper-evident skin and active RFID with a secure information system, and the capability of arming and monitoring the system, with local communications for reporting any integrity breach. Physical Optics Corporation (POC) proposes to develop a new four-security-layer Secure Parcel ISO Distributed Enhanced RFID (SPIDER) system based on: smart electric skin with conductive ink; unique RFID communication with container; protection against sophisticated intrusion; geospatial analysis tracking, and software for effective manipulation and analysis of parcel status in a Web-GIS environment. In Phase I POC will design the critical material, electronic, and software components, and develop a working prototype for the first two security layers of the SPIDER. Phase II will culminate in a SPIDER fully functional prototype. POC's experience in the web-imprinting-fabrication process, electronic packaging, electronic components, and GIS not only ensures the smooth integration of SPIDER into U.S. Homeland Security ACSD and MATTS but also will attract investment to enter the international container shipping and global logistics markets. The integration of POC's cost-effective SPIDER technology into the ACSD and MATTS programs for secure ISO containers will increase the productivity and accuracy of these tools. POC's SPIDER not only meets the major DHS requirements for cargo integrity monitoring, but also has significant commercial applications in international intermodal shipping and global logistics.

Company

Pharad, LLC
797 Cromwell Park Drive
Suite V
Glen Burnie, MD 21061-2540

Proposal Information 0511071 - Low-Cost Secure Carton System using Electrically Conducting Fabric
Topic Information H-SB05.1-006 - SECURE CARTON SYSTEM
Award/Contract Number NBCHC050110
Abstract

Pharad proposes to design and develop technologies for the realization of a low-cost novel 'Secure Carton' which can detect tampering and physical intrusions. Our secure carton will also provide communication of the carton condition/status in real-time to the Advanced Container Security Device via an encrypted data link. The basis of our concept for a 'carton-centric' approach to intermodal container security is a secure carton which is made of an electrically conducting woven fabric or textile impregnated with a strengthening resin material that defends the physical security boundary of the carton. Any tampering activity or physical intrusion of the carton walls changes the material electrical characteristics which is detected and generates an alarm indicating that the integrity of the carton has been compromised. We will investigate suitable electrically conducting fabrics/textiles and resin materials for the physical skin of our novel secure carton. We will also develop a low-cost architecture for the tamper detection mechanism and develop the optimal electrical interconnection between the conducting fabric and the RFID tag. We will also carry out a simplified experimental proof of concept demonstration confirming the feasibility of detecting carton breaches or tampering via our novel physical electronic enclosure and tamper detection circuit.

Company

Mariner Container Corp.
PO Box 873
3821 North Main Street
Granite Falls, NC 28630-0000

Proposal Information 0511149 - "SMART" HYBRID CONTAINER SYSTEM
Topic Information H-SB05.1-006 - SECURE CARTON SYSTEM
Award/Contract Number NBCHC050105
Abstract

The global economy has brought about enormous opportunities in the areas of trade with developing nations. Nowhere is it more evident than in the East Asian basin. In 2002, over 12 million TEU containers where imported into the U.S. with over 60% originating in China/Hong Kong. In the same year, only 7 million TEU containers where exported from the U.S. to the rest of the world. What happened to those 5 million TEU empty containers? Shipping of steel containers (both full and empty) poses several problems to Homeland Security and shipping companies. RFID systems will not operate in steel containers because of wave propagation and false signals. X-ray systems must be extremely powerful (3MeV to 6Mev systems) to penetrate steel siding and can only review 20 containers per hour per system. At a 50% return rate, the shipping of empty containers is an expensive choice for shipping companies. Steel, while strong, rusts in marine environment. Mariner Container Corp. is ready to take advantage of opportunities available in today's global intermodal transportation market by providing a quantum increase in the level of detection, protection, tracking, recycling, and advanced manufacturing processes of a hybrid recyclable plastic 40' "smart" merchant ship containers.

Company

Mide Technology Corporation
200 Boston Avenue Suite 1000
Medford, MA 02155-4242

Proposal Information 0511235 - Resitively Encoded Materials for Secure Carton Systems
Topic Information H-SB05.1-006 - SECURE CARTON SYSTEM
Award/Contract Number NBCHC050109
Abstract

The proposed development is an innovative resistively encoded material used either as a layer in a carton box or as a layer in packaging tape. The innovation uses a number of conductive strips, which are randomly conductively connected to form a unique material that can be used to secure cartons and packages. Interrogation of the resistance between the strips allows an electronic "signature" to be obtained that is unique to the carton and or tape. This unique identification signature will be compressed, encoded and added as a barcode to the package. Any attempts to open or breach the package will change the strip to strip resistances, thus changing the identification signature, which allows security personnel to quickly identify tampered packages. The "signature" may be monitored and transmitted though RFID technology to a monitor placed inside an ISO inter-modal shipping container. This will allow continuous monitoring of carton containers inside a shipping container. A low cost solution that will protect carton containers against tampering has a huge commercial opportunity. The "encoded" layer may be easily integrated into cartons or packaging tapes. The cost of these products will be marginally increased, thus facilitating wide acceptance from fabricators, distributors and users.

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