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Award Information
Proposal Number: 0522004
Proposal Title: Handheld Biosensor with Multiplexed Immunoassays, Genomic DNA Testing and Orthogonal Detection Protocols for First Responder Applications
Topic Number: H-SB05.2-001
Phase: Phase II
Organization: Seahawk Biosystems Corporation
Address: 3000 Bryker Drive
Austin, TX 78703-1834  
Abstract: Since 9/11, a distinct probability exists that terrorist will attempt another attack with chemical or biowarfare agents. Consequently, the Department of Homeland Security requires a network of sensor technologies to defend against this threat. As part of the solution for DHS, Seahawk Biosystems is developing the handheld Talon Biosensor for rapid, low-cost multiplexed detection of proteins and nucleic acids. The Talon Biosensor performs quantitative, immunodiagnostic and DNA tests. Advantages of the Talon Biosensor include non-optical, direct on-chip detection; easy to use, compact hardware; minimal sample preparation; < 10 minute assay time; high sensitivity with low false positive rates; and low cost. It is a valuable asset for DHS as well as the veterinary, environmental and human clinical markets. During Phase I, Seahawk demonstrated feasibility of packaging the Talon Biosensor in a portable handheld form factor and discriminating between ricin and SEB in multiplexed assays. System sensitivity is at 10pM for immunoassays and 10fM for DNA assays with 95% detection confidence, false positive rates are 10-16 for 10 nM samples. Phase II focuses on 1) assay performance benchmarks for both immunoassays and DNA tests, 2) extracting genomic DNA, 3) multiplexed and orthogonal assay protocols and demonstrations, and 4) reader/cartridge prototype development.
Award/Contract Number: D07PC75283 (formerly NBCHC070091)
Period of Performance: 04/30/2007 - 06/30/2009
Award/Contract Value: $750,000.00
Award/Obligated Amount: $750,000.00