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Award Information
Proposal Number: 0521268
Proposal Title: BioPhalanx, a hand portable discrete monolithic microarray biothreat detector
Topic Number: H-SB05.2-001
Phase: Phase I
Organization: Arcxis Biotechnologies
Address: 18858 Carlton Ave
Castro Valley, CA 94546-2908  
Abstract: The focus of this proposal is to develop BioPhalanx a rapid, hand portable, robust detection system for multiplexed detection of bio-threats, in harsh environments. We have developed a new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability. This type of analysis will greatly reduce false positives and false negatives; in addition it is reusable and eliminates special storage requirements for reagents. The Arcxis Biotechnologies team has realized specific technical advancements in the optimization of hybridization assays for nucleic acid detection on porous polymer monoliths (PPM). We have further developed the ability to perform rapid and complete solubilisation of viruses, vegetative bacteria and bacterial spores with an ultra high temperature solubilisation protocol. Combining these proprietary technologies provides the ability to perform rapid highly multiplexed analysis of a variety of bioagents, including bacteria viruses, and protein biotoxins. The BioPhalanx system is designed to perform completely automated sample preparation and analysis, in a time frame of five minutes or less. The assay is simple in design allowing users in personal protective equipment to easily operate the system. In all, the proposed BioPhalanx system is robust, simple to use, and addresses the goals of DHS and the first responder community.
Award/Contract Number: NBCHC060031
Period of Performance: 12/15/2005 - 06/30/2006
Award/Contract Value: $100,000.00
Award/Obligated Amount: $100,000.00